Cancer Gene Therapy
Researchers' work from University of Pennsylvania focuses on cancer gene therapy
Published in Proteomics Weekly, January 8th, 2007
New investigation results, "AHNP-streptavidin: a tetrameric bacterially produced antibody surrogate fusion protein against p185her2/neu," are detailed in a study published in Oncogene. According to recent research published in the journal Oncogene, "The anti-p185(her2/neu) peptidomimetic (AHNP) is a small exo-cyclic peptide derived from the anti-p185(her2/neu) rhumAb 4D5 (h4D5). AHNP mimics many but not all of the antitumor characteristics exhibited by h4D5."
"However, the pharmacokinetic profiles of AHNP are less than optimal for therapeutic or diagnostic purposes. To improve the binding affinity to p185(her2/neu) and the antitumor efficacy, we have engineered a...
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Source: Proteomics Weekly (2007-01-08)
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