Hepatocellular Cancer Therapy
Data from INSERM provide new insights into hepatocellular cancer therapy
Published in Proteomics Weekly, February 19th, 2007
Researchers detail in "Pravastatin reduces lung metastasis of rat hepatocellular carcinoma via a coordinated decrease of MMP expression and activity," new data in hepatocellular cancer. "Statins have beneficial effects in early pre-clinical models of hepatocellular carcinoma (HCC). Our aim was to test the efficacy of pravastatin on the progression of established HCC in rat, and to study its mechanisms," scientists in Bordeaux, France report.
"HCC was induced with diethylnitrosamine and N-nitrosomorpholine. After 14 weeks, all rats developed HCC and then received pravastatin or its solvent for 10 weeks (10 rats/group). Liver tumor mass was lower in pravastatin group (PG)...
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Source: Proteomics Weekly (2007-02-19)
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