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Meningitis

454 Sequencing Reveals Novel Aspects of a Human Pathogen

Published in Proteomics Weekly, March 12th, 2007

454 Life Sciences Corp., a majority-owned subsidiary of CuraGen Corp. (NASDAQ:CRGN), announced that researchers at Yale University using the company's Genome Sequencer system have determined the pathogenic content of A. baumannii, a bacteria responsible for several infections, including pneumonia, meningitis and those of the urinary tract.

Published in a paper in Genes & Development, the results reveal that A. baumannii devotes a considerable portion of its genes to pathogenesis. Sequencing identified a large amount of foreign bacterial DNA incorporated into the A. baumannii genome and also helped to identify virulence genes that lack homology with other known genes....

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