DNA Research

Scientists reveal structure of gateways to gene control

Published in Proteomics Weekly, April 9th, 2007

Scientists at Penn State University revealed in the journal Nature the first complete high-resolution map of important structures that control how genes are packaged and regulated throughout an entire genome.

"For the first time, we are seeing in very high resolution on a genome-wide scale how nucleosomes control the expression of an organism's genes," said B. Franklin Pugh, professor of biochemistry and molecular biology and the study's lead investigator.

The map pinpoints the locations of certain key gene-controlling nucleosomes -- spool-like structures that wrap short regions of DNA around a protein core. The research suggests how these...

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Source: Proteomics Weekly (2007-04-09)

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