Gene Therapy
Studies from Hospital for Sick Children, Division of Hematology-Oncology yield new information about gene therapy
Published in Proteomics Weekly, April 16th, 2007
New research, "Cyclooxygenase inhibitors modulate the p53/HDM2 pathway and enhance chemotherapy-induced apoptosis in neuroblastoma," is the subject of a report. According to a study from Toronto, Canada, "Cyclooxygenase-2 (COX-2) is upregulated in many tumors including neuroblastoma, and its overexpression has been implicated in resistance to p53-dependent apoptosis. Although p53 is rarely mutated in neuroblastoma, the p53 protein is rendered inactive via several mechanisms including sequestration in the cytoplasm."
"Here, we show that COX inhibitors inhibit the growth of neuroblastoma and when combined with low doses of chemotherapy, exert synergistic effects on...
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Source: Proteomics Weekly (2007-04-16)
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