Hypertrophy Cell Biology

Research from Baker Heart Research Institute provides new data on hypertrophy cell biology

Published in Proteomics Weekly, April 16th, 2007

Data detailed in "Relaxin antagonizes hypertrophy and apoptosis in neonatal rat cardiomyocytes" have been presented. "The pregnancy hormone relaxin has recently been shown to be cardio-protective. Despite its well-established antifibrotic actions in the heart, the effects of relaxin on cardiomyocytes (CM) remain to be determined," researchers in Melbourne, Australia report.

"We investigated effects of isoform 2 of the human relaxin (H2-relaxin) on CM hypertrophy and apoptosis. In cultured neonatal rat CM, phenylephrine (50 microM) and cardiac fibroblast-conditioned medium were used respectively to induce CM hypertrophy. The degree of hypertrophy was indicated by...

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Source: Proteomics Weekly (2007-04-16)

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