Immunology
Researchers at Jagiellonian University release new data on immunology
Published in Proteomics Weekly, April 16th, 2007
A new study, "Staphylococcus aureus-derived staphopain B, a potent cysteine protease activator of plasma chemerin," is now available. "Chemerin is an attractant for cells that express the serpentine receptor CMKLR1, which include immature plasmacytoid dendritic cells (pDC) and macrophages. Chemerin circulates in the blood where it exhibits low biological activity, but upon proteolytic cleavage of its C terminus, it is converted to a potent chemoattractant," scientists in Krakow, Poland report.
"Enzymes that contribute to this conversion include host serine proteases of the coagulation, fibrinolytic, and inflammatory cascades, and it has been postulated that recruitment...
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Source: Proteomics Weekly (2007-04-16)
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