Arthritis Immunology
Investigators at University Hospital, Department of Orthopedic Surgery zero in on arthritis immunology
Published in Proteomics Weekly, April 16th, 2007
A report, "Attachment to laminin-111 facilitates transforming growth factor beta-induced expression of matrix metalloproteinase-3 in synovial fibroblasts," is newly published data in Annals of the Rheumatic Diseases. "In the synovial membrane of patients with rheumatoid arthritis (RA), a strong expression of laminins and matrix degrading proteases was reported. To investigate the regulation of matrix metalloproteinases (MMPs) in synovial fibroblasts (SFs) of patients with osteoarthritis (OA) and RA by attachment to laminin-1 (LM-111) and in the presence or absence of costimulatory signals provided by transforming growth factor beta (TGFbeta)," investigators in Germany report.
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Source: Proteomics Weekly (2007-04-16)
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