Diabetes
Researchers from National Institute of Diabetes and Digestive and Kidney Disease report on findings in diabetes
Published in Proteomics Weekly, April 16th, 2007
Data detailed in "Requirements for DNA hairpin formation by RAG1/2" have been presented. "The rearrangement of antigen receptor genes is initiated by double-strand breaks catalyzed by the RAG1/2 complex at the junctions of recombination signal sequences and coding segments. As with some "cut-and-paste" transposases, such as Tn5 and Hermes, a DNA hairpin is formed at one end of the break via a nicked intermediate," scientists in the United States report.
"By using abasic DNA substrates, we show that different base positions are important for the two steps of cleavage. Removal of one base in the coding flank enhances hairpin formation, bypassing a requirement for a paired...
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Source: Proteomics Weekly (2007-04-16)
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