Biological Chemistry
Studies from Medical College of Wisconsin, Department of Microbiology add new findings in the area of biological chemistry
Published in Proteomics Weekly, April 23rd, 2007
Investigators publish new data in the report "Mechanism of substrate recognition by botulinum neurotoxin serotype A." According to a study from the United States, "Botulinum neurotoxins (BoNTs) are zinc proteases that cleave SNARE proteins to elicit flaccid paralysis by inhibiting neurotransmitter-carrying vesicle fusion to the plasma membrane of peripheral neurons. Unlike other zinc proteases, BoNTs recognize extended regions of SNAP25 for cleavage; however, the molecular basis for this extended substrate recognition is unclear."
"Here, we define a multistep mechanism for recognition and cleavage of SNAP25 by BoNT/A. SNAP25 initially binds along the belt region of...
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Source: Proteomics Weekly (2007-04-23)
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