Published in Proteomics Weekly, June 11th, 2007
Cancer-causing mutations in the BRCA1 protein cause it to fail to bind to the Rap80 protein. Consequently, BRCA1 is unable to identify DNA damage sites in the genome. When BRCA1 fails to fix DNA damage, cancer-causing mutations accumulate, spawning the development of breast and ovarian malignancies.
“With this current discovery, we have made...
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