Findings from Medical University of Vienna, Department of Dermatology provide new insights into biofilms

A new study, "DNase1L2 suppresses biofilm formation by Pseudomonas aeruginosa and Staphylococcus aureus," is now available. According to a study from Vienna, Austria, "The formation of biofilms, which is an important step in bacterial colonization, can be inhibited by deoxyribonuclease (DNase)-mediated breakdown of extracellular DNA. We have recently demonstrated that epidermal keratinocytes strongly express DNase1-like 2 (DNase1L2) in a differentiation-associated manner. To determine whether enzymatically active DNase1L2 is present in human stratum corneum and whether it is able to suppress bacterial biofilm formation."

"DNase1L2 was extracted from normal human stratum...

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