Pharmaceutical Sciences

Study results from Simcyp Limited provide new insights into pharmaceutical sciences

Published in Proteomics Weekly, September 3rd, 2007

Investigators publish new data in the report "Theoretical assessment of a new experimental protocol for determining kinetic values describing mechanism (time)-based enzyme inhibition. We have shown previously that the conventional experimental protocol (CEP) used to characterise mechanism-based enzyme inhibition (MBI) of drug metabolism in vitro may introduce substantial bias in estimates of the relevant kinetic parameters. The aim of this study was to develop and assess, by computer simulation, an alternative, mechanistically-based experimental protocol (MEP)," investigators in Sheffield, the United Kingdom report.

"This protocol comprises three parts viz. assessment...

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Source: Proteomics Weekly (2007-09-03)

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