Biomedicine
Study results from Hanyang University, Institute of Biomedical Science broaden understanding of biomedicine
Published in Proteomics Weekly, September 24th, 2007
A report, "Role of phospholipase D2 in anti-apoptotic signaling through increased expressions of Bcl-2 and Bcl-xL," is newly published data in Journal of Cellular Biochemistry. According to recent research from Seoul, Korea, "We have previously reported that Fas-resistant A20 cells (FasR) have phospholipase D (PLD) activity upregulated by endogenous PLD2 overexpression. In the present study, we investigated how overexpressed PLD2 in FasR could generate survival signals by regulating the protein levels of anti-apoptotic Bcl-2 and Bcl-xL."
"To confirm the effect of PLD2 on Bcl-2 protein levels, we transfected PLD2 into wild-type murine B lymphoma A20 cells. The...
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Source: Proteomics Weekly (2007-09-24)
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