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Drug Resistance

New insight into how antibiotics kill might make them deadlier

Published in Proteomics Weekly, September 24th, 2007

Scientists have what could be some very bad news for disease-causing bacteria. All three major classes of antibiotics that kill infectious bacteria do so in part by ramping up the production of harmful free radicals, researchers report in Cell, a publication of Cell Press. Because those different types of antibiotics each initially hit different targets, it had been believed they worked by independent means.

The findings could point the way to new classes of antibiotics and to a common method by which existing antibiotics could be made to stamp out bacteria even better, according to the Boston University researchers. Such advances are particularly critical at a time...

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