Ischemia

New findings from J.P. Roesner and co-researchers in the area of ischemia described

Published in Proteomics Weekly, September 24th, 2007

"The fibrin-derived peptide B beta(15-42) has been shown to reduce infarct size in rodent models of ischemia-reperfusion injury. To increase its potential for translation into the clinic, we studied the effects of B beta(15-42) in pigs, whose coronary anatomy is similar to that of humans," scientists in Rostock, Germany report.

"In addition, we evaluated the pharmacokinetics and safety of B beta(15-42) in several species, including humans. Animal study and phase I trial. University hospital and contract research laboratories. Pigs/healthy volunteers. Male farm-bred Landrace pigs were subjected to 1 hr of left anterior descending coronary artery occlusion followed by 3...

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Source: Proteomics Weekly (2007-09-24)

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