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Cell Biology

Scientists at Pontificia University Catolica of Chile, Medical Research Center discuss research in cell biology

Published in Proteomics Weekly, October 1st, 2007

Fresh data on cell biology are presented in the report "D-glucose stimulation of L-arginine transport and nitric oxide synthesis results from activation of mitogen-activated protein kinases p42/44 and Smad2 requiring functional type II TGF-beta receptors in human umbilical vein endothelium." According to a study from Santiago, Chile, "Elevated extracellular D-glucose increases transforming growth factor beta1 (TGF-beta1) release from human umbilical vein endothelium (HUVEC). TGF-beta1, via TGF-beta receptors I (TbetaRI) and TbetaRII, activates Smad2 and mitogen-activated protein kinases p44 and p42 (p42/44(mapk))."

"We studied whether D-glucose-stimulation of L-arginine...

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