Gene Therapy

Research data from Y. Onishi and colleagues update understanding of gene therapy

Published in Proteomics Weekly, December 10th, 2007

According to a study from Seto, Japan, "A stable and soapless latex of diethylaminoethyl-dextran-methyl methacrylate (DEAE-dextran-MMA) graft copolymer (DDMC) has been developed for nonviral gene delivery vectors that are possible to autoclave. DDMC relatively easily formed a polyion complex between DNA and DDMC by the hydrophobic force of graft poly(MMA) depending on its large positive entropy change (AS)."

"DDMC has been confirmed as having a high protection facility for DNase by DNase degradation test. Transfection activity was determined using the beta-galactosidase assay, and a higher value of 16 times or more was confirmed for the DDMC samples in comparison with...

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Source: Proteomics Weekly (2007-12-10)

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