Lupus

Research in the area of lupus reported from A. Sharabi and colleagues

Published in Proteomics Weekly, December 10th, 2007

"Experimental systemic lupus erythematosus (SLE) can be induced in mice following immunization with an anti-DNA mAb expressing a major Id, 16/6Id. Treatment with a peptide, designated human CDR1 (hCDR1; Edratide), that is based on the sequence of CDR1 of the 16/61d ameliorated disease manifestations," scientists in Rehovot, Israel report.

"In the present study, we investigated the roles of apoptosis and related molecules in BALB/c mice with induced experimental SLE following treatment with hCDR1. A higher state of activation and increased rate of apoptosis were found in lymphocytes of SLE-afflicted mice as compared with healthy controls. The latter effects were...

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Source: Proteomics Weekly (2007-12-10)

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