Apoptosis
Research from Medical University of South Carolina provides new data on apoptosis
Published in Proteomics Weekly, December 10th, 2007
A report, 'Cooperation between JNK1 and JNK2 in activation of p53 apoptotic pathway,' is newly published data in Oncogene. "FDH (10-formyltetrahydrofolate dehydrogenase) is strongly downregulated in tumors while its elevation suppresses proliferation of cancer cells and induces p53-dependent apoptosis. We have previously shown that FDH induces phosphorylation of p53 at Ser6, which is a required step in the activation of apoptosis," scientists writing in the journal Oncogene report.
"In the present study, we report that FDH-induced p53 phosphorylation is carried out by JNK1 and JNK2 (c-Jun N-terminal kinases) working in concert. We have demonstrated that...
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Source: Proteomics Weekly (2007-12-10)
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