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Nephropathy

Reports outline nephropathy study results from Peking University

Published in Proteomics Weekly, January 14th, 2008

"IgA nephropathy (IgAN) is a polygenic disorder. Increasing evidence has implicated that aberrant glycosylation of IgA1 molecules, including alpha 2,6 sialic acid defects, are involved in the pathogenesis of IgAN," researchers in Beijing, People's Republic of China report.

"In the present study, we designed an association study to investigate polymorphisms of two important genes, ST6GALNAC2 and NEU1, which are involved in the sialylation of the IgA1 molecule, in the susceptibility to IgAN. A total of 670 patients with histologically proven IgAN and 494 healthy controls were enrolled. Screening of SNPs in the coding and promoter regions of the ST6GALNAC2 and NEU1 genes...

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