Pancreatic Cancer

Research reports from J.K. Lee and co-authors provide new insights into pancreatic cancer

Published in Proteomics Weekly, January 14th, 2008

"Background & Alms: Growth factors, such as insulin-like growth factor-1 (IGF-I), protect pancreatic cancer (PaCa) cells from death. We recently showed that reactive oxygen species (ROS) produced by nicotinamide adenine dinucleotide phosphate (NADPH) oxidase Nox4 mediate the antiapoptotic effect of growth factors," scientists in the United States report.

"Here, we examine the mechanisms of the antiapoptotic role of NADPH oxidase. We hypothesized that ROSS produced by NADPH oxidase inhibit key protein tyrosine phosphatases (PTPs) and thus sustain the activation of kinases mediating antiapoptotic pathways in PaCa cells. Transfections and pharmacologic inhibition were used...

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Source: Proteomics Weekly (2008-01-14)

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