Leukemia Cell Biology
Study results from Second Military Medical University, Department of Hematology provide new insights into leukemia cell biology
Published in Proteomics Weekly, March 17th, 2008
Research findings, 'Cu2+ is required for pyrrolidine dithiocarbamate to inhibit histone acetylation and induce human leukemia cell apoptosis,' are discussed in a new report. "Pyrrolidine dithiocarbamate (PDTC) has been considered as a potential anticancer drug due to its powerful apoptogenic effect towards cancer cells, where Cu(2+) plays a distinct yet undefined role. Here we report that Cu(2+) is critically needed for PDTC to inhibit histone acetylation in both human leukemia HL-60 cells and human hepatoma Hep3B cells," researchers in Shanghai, People's Republic of China report.
"The inhibition of histone acetylation mainly resulted from the increase of intracellular...
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Source: Proteomics Weekly (2008-03-17)
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