Cardiology

Studies from Dokkyo University, Medical Department have provided new data on cardiology

Published in Proteomics Weekly, March 17th, 2008

"We have known that endothelial nitric-oxide synthase (eNOS) and oxidative stress may play a key role in cardiac performance in failing rat hearts. However, the interactions between eNOS or oxidative stress and bradykinin (BK) under treatment of calcium channel blockers (CCBs) remain unknown," researchers in Mibu, Japan report.

"To elucidate the mechanism underlying the cardiciprotective effect of long-acting dihydropyridine CCBs, we evaluated the effect of benidipine on the BK-eNOS and NAD(P)H oxidase pathway in Dahl salt-sensitive (DS) rats with heart failure. 11-week-old DS rats were treated with one of the following drug combinations for 7 weeks until the onset of...

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Source: Proteomics Weekly (2008-03-17)

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