Enzyme Research

Research by K.Y. Vinod and colleagues in enzyme research provides new insights

Published in Proteomics Weekly, March 17th, 2008

According to recent research from the United States, "The aim of this study was to examine the role of fatty acid amide hydrolase (FAAH) on ethanol sensitivity, preference, and dependence. The deletion of FAAH gene or the inhibition of FAAH by carbamoyl-biphenyl-3-yl-cyclohexylcarbamate (URB597) (0.1 mg/kg) markedly increased the preference for ethanol."

"The study further reveals that URB597 specifically acts through FAAH and that cannabinoid-1 (CB1) receptor is critical for N-arachidonoyl ethanolamide (AEA) mediated ethanol-reinforced behavior as revealed by lack of URB597 effect in both FAAH and CB1-/- mice compared with vehicle-treated -/- mice. The FAAH -/- mice...

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Source: Proteomics Weekly (2008-03-17)

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