Neuroblastoma

Research reports from A. Delaune and co-authors provide new insights into neuroblastoma

Published in Proteomics Weekly, March 17th, 2008

According to a study from Rouen, France, "Neuroblastoma is one of the most common cancers in children. Neuroblastoma differentiation is linked to the presence of the promyelocytic leukemia (PML) protein."

"Retinoic acid, a powerful differentiation-inducer in vitro, is a potent agent for the treatment of neuroblastoma. Using two different human neuroblastoma cell lines, SH-SY5Y and LA-N-5, we show here that PML protein leads to the formation of nuclear bodies (PML-NB) after only 1 h of retinoic acid treatment and that this formation is mediated by the extracellular signal-regulated kinase (ERK) pathway. Inhibition of protein kinase C also leads to formation of PML-NB via...

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Source: Proteomics Weekly (2008-03-17)

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