Glioblastoma

Reports from University of Minnesota describe recent advances in glioblastoma

Published in Proteomics Weekly, March 17th, 2008

"To improve activity of a recombinant IL-13 cytotoxin (CT) comprised of IL-13 spliced to truncated diphtheria toxin (DT390), epidermal growth factor (EGF) was added to the same single chain protein. This new recombinant bispecific CT, called DTEGF13, enhanced the killing potency against the human glioblastoma lines, U87MG (0.015 nM) and U118MG (0.02 nM)," scientists writing in the Journal of Neuro - Oncology report.

"A similar enhancement was observed against the lung carcinoma cell line, Calu-3 (0.0018 nM). Enhanced activity could not be explained by an increased number of cytokines available for binding since a combination of monospecific DTEGF and DTIL13 did...

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Source: Proteomics Weekly (2008-03-17)

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