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Neuroblastoma Therapy

Findings from City University of New York, Department of Biological Sciences broaden understanding of neuroblastoma therapy

Published in Proteomics Weekly, March 24th, 2008

Current study results from the report, 'p38 MAPK as a negative regulator of VEGF/VEGFR2 signaling pathway in serum deprived human SK-N-SH neuroblastoma cells,' have been published. "Evidence suggests that vascular endothelial growth factor (VEGF) mediates neuroprotection to prevent an apoptotic cell death. The p38 mitogen-activated protein kinase (MAPK) pathway is implicated as an important mediator of neuronal apoptosis but its role in VEGF-mediated neuroprotection is unclear," researchers in the United States report.

"Herein, we show that treatments with the p38 MAPK inhibitor, SB202190, enhanced VEGF-mediated survival in serum deprived SK-N-SH neuroblastoma cells by...

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