Crohn Disease

Caspase-12: MUHC researcher finds new defense mechanism against intestinal inflammation

Published in Proteomics Weekly, March 24th, 2008

The body's first line of defence against pathogenic bacteria that we ingest may not be the immune system but rather the cells that line the intestine. This surprising conclusion is just one facet of a study by Dr. Maya Saleh, a researcher at the Research institute of the McGill University Health Centre that will be published in the journal Cell Host & Microbe on March 12.

This, and the various mechanisms revealed by this discovery, could lead to important therapeutic innovations, particularly in the treatment of diarrheal diseases and inflammatory bowel diseases such as Crohn's disease.

When pathogenic E. coli bacteria infect the body, they bind to...

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Source: Proteomics Weekly (2008-03-24)

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