Supramolecular Research

New supramolecular research from Georgetown University discussed

Published in Proteomics Weekly, March 24th, 2008

According to recent research from the United States, "The functions of evolved mammalian supramolecular assemblies and extensions of enzymes are not well understood. Human lysyl-tRNA synthetase (hKRS) only upon the removal of the amino-terminal extension (hKRS Delta 60) bound to EF1 alpha and was stimulated by EF1 alpha hi vitro."

"HKRS and hKRS Delta 60 were also differentially stimulated by aspartyl-tRNA synthetase (AspRS) from the multi-synthetase complex. The non-synthetase protein from the multi-synthetase complex p38 alone did not affect hKRS lysylation but inhibited the AspRS-mediated stimulation of hKRS," wrote C.M. Guzzo and colleagues, Georgetown...

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Source: Proteomics Weekly (2008-03-24)

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