Published in Proteomics Weekly, June 30th, 2008
"We report reduced numbers of maturing leukocytes but elevated levels of undifferentiated 3Sca-1(+)/c-Kit(+)/Lin(-) cells in the bone marrow (BM) of mice overexpressing heparanase (hpa-Tg). This resulted from increased proliferation and retention of the primitive cells in the BM microenvironment, manifested in increased SDF-1 turnover. Furthermore, heparanase overexpression in...
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