Retrovirus

Studies from G.B. Mortuza et al in the area of retrovirus described

Published in Proteomics Weekly, June 30th, 2008

According to a study from Mill Hill, the United Kingdom, "The Gag polyprotein is the major structural protein found in all classes of retroviruses. Interactions between Gag molecules control key events at several stages in the cycle of infection."

"In particular, the capsid (CA) domain of Gag mediates many of the protein-protein interactions that drive retrovirus assembly, maturation and disassembly. Moreover, in murine leukaemia virus (MLV), sequence variation in CA confers N and B tropism that determines susceptibility to the intracellular restriction factors Fv1n and Fv1b. We have determined the structure of the N-terminal domain (NtD) of CA from B-tropic MLV. A...

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Source: Proteomics Weekly (2008-06-30)

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