Drug Development
Study results from University of Dundee update understanding of drug development
Published in Proteomics Weekly, September 15th, 2008
"The increasing number of transgenic or gene knockout mouse models generated for use in drug metabolism studies has meant that a greater understanding of the function and substrate specificities of murine cytochromes P450 (P450s) has become essential, particularly with the recent advances in ''humanized'' mouse models. In this study, we have heterologously expressed nine murine P450s-Cyp1a1, Cyp1a2, Cyp1b1, Cyp2a4, Cyp2b20, Cyp2c29, Cyp2d22, Cyp2e1, and Cyp3a11 - individually with human P450 oxidoreductase to generate functional monooxygenase systems in Escherichia coli," scientists writing in the journal Drug Metabolism and Disposition report.
"We have...
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Source: Proteomics Weekly (2008-09-15)
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