A report, 'Novel isosorbide di-ester compounds as inhibitors of acetylcholinesterase,' is newly published data in Chemico-Biological Interactions. "We report herein that a variety of isosorbide di-esters, previously reported to be novel substrates for butyrylcholinesterase (BuChE, EC 18.104.22.168), are in fact inhibitors of the homologousenzyme acetylcholinesterase (AChE), with IC(50) values in the micromolar range. In vitro studies show that they are mixed inhibitors of the enzyme, and thus the ternary enzyme-inhibitor-substrate complex can form in acetylcholinesterase," scientists in Dublin, Ireland report.
"This is rationalised by molecular modelling which shows...
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