Proteomics Weekly
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Proteomics Weekly
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Alzheimer Disease
Scientists at University of Brescia target Alzheimer disease
February 23rd, 2009
According to recent research from Brescia, Italy, "Decay of mitochondria, energy failure and increased oxidative stress are features commonly detected in brains from Alzheimer's disease (AD) patients. Recent findings indicate that neuronal heme deficiency may contribute to the appearance of those cytopathologies and potentially alter the course of AD." "We repressed heme synthesis in cells by inhibiting ferrochelatase enzyme with small interfering RNA and N-methylprotoporphyrin IX. The treatments induced a severe perturbation of mitochondria and energy production, with decrease of the subunit II of Cytochrome c Oxidase, alteration of the membrane potential and a 50%...
Source: Proteomics Weekly (2009-02-23)
|
