Mayo Clinic

Mayo researchers discover mechanism of cell type-specific signaling in tumor development

Published in Proteomics Weekly, April 20th, 2009

Mayo Clinic researchers have discovered the mechanisms behind two key checkpoints in cell growth and development — factors that may ultimately allow investigators to benchmark progression of tumor cells or stop them from further development. The findings appear in the current online issue of Developmental Cell.

The team led by Edward Leof, Ph.D., Mayo Clinic biochemist, demonstrated that p21-activated kinase 2 (PAK2), a key target for cancer growth and fibrotic tissue development, is activated in one type of tissue but not another. PAK2 is a downstream component of transforming growth factor beta (TGF-) signaling in mesenchymal cells — those that make up connective...

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Source: Proteomics Weekly (2009-04-20)

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