Fusion Proteins

Reports outline fusion proteins research from O. Ramadan and colleagues

Published in Proteomics Weekly, April 20th, 2009

"The novel alpha(1D) L-type Ca2+ channel is expressed in supraventricular tissue and has been implicated in the pacemaker activity of the heart and in atrial fibrillation. We recently demonstrated that PKA activation led to increased alpha(1D) Ca2+ channel activity in tsA201 cells by phosphorylation of the channel protein," scientists writing in the Journal of Biological Chemistry report.

"Here we sought to identify the phosphorylated PKA consensus sites on the alpha(1) subunit of the alpha(1D) Ca2+ channel by generating GST fusion proteins of the intracellular loops, N terminus, proximal and distal C termini of the alpha(1) subunit of alpha(1D) Ca2+ channel. An...

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Source: Proteomics Weekly (2009-04-20)

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