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Protease
Studies by C. Doucette and co-authors describe new findings in protease
June 15th, 2009
A new study, 'Kappa opioid receptor screen with the Tango beta-arrestin recruitment technology and characterization of hits with second-messenger assays,' is now available. According to recent research from the United States, "Assays for high-throughput screening of G-protein-coupled receptors (GPCRs) have typically revolved around receptor binding, guanine nucleotide binding, and second-messenger assays measuring intracellular cAMP and calcium levels. New assay development has been directed toward G-protein-independent signaling pathways, including protein redistribution in response to activated receptors. beta-arrestin recruitment to agonist-stimulated GPCRs is the basis for the...
Source: Proteomics Weekly (2009-06-15)
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