Apoptosis

New findings in apoptosis described by D. Tews and co-researchers

Published in Proteomics Weekly, June 29th, 2009

According to a study from Dusseldorf, Germany, "Glucagon like peptide-1 (Glp-1) exhibits beneficial effects oil beta cell mass by both enhancing proliferation and inhibiting apoptosis. The precise mechanism of the anti-apoptotic effect of Glp-1 and Glp-1 mimetics like exendin-4 has remained elusive."

"Here, we studied cytokine-induced apoptosis in the pancreatic beta cell line INS-1 and performed a comparative mitochondrial protein pattern analysis using two-dimensional difference gel electrophoresis (2D-DIGE). Cytokine incubation of INS-1 cells increased caspase-3 activity about 3-fold, Which was reduced by 60% in the presence of exendin-4. Production of reactive...

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Source: Proteomics Weekly (2009-06-29)

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