Coagulation

Study results from University of Duisburg-Essen broaden understanding of coagulation

Published in Proteomics Weekly, August 10th, 2009

"During Gram-negative sepsis, lipopolysaccharide (LPS) Stimulates toll-like receptor 4, resulting in an activation of the immune system and the expression of tissue factor on monocytes. As a consequence, intravascular coagulation, ischemia, and multiorgan dysfunction may occur," scientists writing in the journal Anesthesia and Analgesia report.

"Because thiopental has been described to modulate the immune system, we tested the hypothesis that thiopental alters the LPS-induced tissue factor expression. (i) Citrated whole blood samples were incubated with thiopental (0, 0.25, 0.5, 1 mg/mL) and LPS (100 mu g/mL) for 4 h. After recalcification, clotting time (CT) was...

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Source: Proteomics Weekly (2009-08-10)

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