DNA Research
Researchers from University of Colorado detail new studies and findings in the area of DNA research
Published in Proteomics Weekly, September 21st, 2009
According to a study from the United States, "The Schizosaccharomyces pombe protection of telomeres 1 (SpPot1) protein recognizes the 3' single-stranded ends of telomeres and provides essential protective and regulatory functions. The ssDNA-binding activity of SpPot1 is conferred by its ssDNA-binding domain, Pot1-DBD (residues 1-389), which can be further separated into two distinct domains, Pot1pN (residues 1-187) and Pot1pC (residues 188-389)."
"Here we show that Pot1pC, like Pot1pN, can function independently of Pot1-DBD and binds specifically to a minimal nonameric oligonucleotide, d(GGTTACGGT), with a K-D of 400 +/- 70 nM (specifically recognized nucleotides in...
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Source: Proteomics Weekly (2009-09-21)
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