Enzyme Research

Research from Aarhus University reveals new findings on enzyme research

Published in Proteomics Weekly, September 21st, 2009

According to recent research published in the journal Biochemistry, "We have characterized a human topoisomerase II alpha enzyme with a deletion of the conserved QTK loop, which extends from the transducer domain to the ATP-binding pocket in the GHKL domain. The loop has been suggested to play a role for interdomain communication in type II topoisomerases."

"The mutant enzyme performs only very low levels of strand passage, although it is able to cleave and ligate DNA as well as close the N-terminal clamp. Cleavage is nearly unaffected by ATP and ATP analogues relative to the wild-type enzyme. Although the enzyme is able to close the clamp, the clamp has altered...

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Source: Proteomics Weekly (2009-09-21)

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