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University of California - San Diego

Malignant signature may help identify patients likely to respond to therapy

Published in Proteomics Weekly, September 21st, 2009

A molecular signature that helps account for the aggressive behavior of a variety of cancers such as pancreatic, breast and melanoma may also predict the likelihood of successful treatment with a particular anti-cancer drug. The finding, which could lead to a personalized approach to treatment for a variety of solid tumors that are currently resistant to therapies, will be published September 6 in the advance online edition of Nature Medicine.

Researchers at the Moores Cancer Center at the University of California, San Diego have discovered that a receptor sitting on the surface of certain aggressive tumor cells can activate a key enzyme, src-kinase, which helps tumor...

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