Life Sciences

Research on life sciences reported by scientists at Medical University of South Carolina

Published in Proteomics Weekly, September 21st, 2009

According to recent research from the United States, "Cytotoxic T lymphocytes (CTL) may undergo massive expansion upon appropriate antigenic stimulation. Homeostasis is maintained by a subsequent ''contraction'' of these cells."

"Activation-induced cell death (AICD) and programmed cell death prevent the untoward side effects, arising from excessive numbers and prolonged persistence of activated CTL, that occur upon uncontrolled and/or continued expansion. However, effector cell persistence has been identified as a hallmark of successful T-cell-mediated adoptive immunotherapy. Thus, prevention of AICD may be critical to achieve more successful clinical results. We have...

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Source: Proteomics Weekly (2009-09-21)

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