Protease

Researchers at University of Florida, Medical Department release new data on protease

Published in Proteomics Weekly, September 21st, 2009

"Differentiation of erythroid cells is regulated by cell signaling pathways including those that change the intracellular concentration of calcium. Calcium-dependent proteases have been shown previously to process and regulate the activity of specific transcription factors," researchers in the United States report.

"We show here that the protein levels of upstream stimulatory factor (USF) increase during differentiation of murine erythroleukemia (MEL) cells. USF was subject to degradation by the Ca2+-dependent protease m-calpain in undifferentiated but not in differentiated MEL cells. Treatment of MEL cells with the specific calpain inhibitor calpeptin increased the...

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Source: Proteomics Weekly (2009-09-21)

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