Acute Myeloid Leukemia

Research on acute myeloid leukemia reported by scientists at University of Toulouse

Published in Proteomics Weekly, September 21st, 2009

According to a study from Toulouse, France, "The t(8:21)(q22;q22) translocation is 1 of the most common chromosomal abnormalities linked to acute myeloid leukemia (AML). AML1-ETO, the product of this translocation, fuses the N-terminal portion of the RUNX transcription factor AML1 (also known as RUNX1), including its DNA-binding domain, to the almost entire transcriptional corepressor ETO (also known as MTG8 or RUNX1T1)."

"This fusion protein acts primarily by interfering with endogenous AML1 function during myeloid differentiation, although relatively few genes are known that participate with AML1-ETO during leukemia progression. Here, we assessed the consequences of...

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Source: Proteomics Weekly (2009-09-21)

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