Chronic Granulomatous Disease Immunology
Studies from University College, Department of Medicine yield new information about chronic granulomatous disease immunology
Published in Proteomics Weekly, September 21st, 2009
Researchers detail in 'Impaired macrophage function following bacterial stimulation in chronic granulomatous disease,' new data in chronic granulomatous disease. According to a study from London, the United Kingdom, "Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase is critical for phagocyte anti-microbial activity and plays a major role in innate immunity. Defects in genes coding for components of the NADPH oxidase enzyme system are responsible for chronic granulomatous disease (CGD), a rare primary neutrophil immunodeficiency associated with recurrent, life-threatening bacterial and fungal infections."
"Microbial killing and digestion within the neutrophil...
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Source: Proteomics Weekly (2009-09-21)
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