Angiotensins
Studies from University of Bonn, Department of Internal Medicine I describe new findings in angiotensins
Published in Proteomics Weekly, October 5th, 2009
Investigators publish new data in the report 'Vascular hyporesponsiveness to angiotensin II in rats with CCl(4)-induced liver cirrhosis.' "Portal hypertension is triggered by vasodilation due to impaired contraction of extrahepatic vessels. Angiotensin II type 1 (AT(1)) receptor-induced vasocontraction is mediated by G proteins and may be desensitized by recruitment of beta-arrestin-2 to the receptor," investigators in Bonn, Germany report.
"In this study, we analysed the interaction of AT(1) receptors with beta-arrestin-2 in the context of vascular hypocontractility in rats with CCl(4)-induced cirrhosis. Micronodular liver cirrhosis in rats (n=15) was induced by...
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Source: Proteomics Weekly (2009-10-05)
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