Life Sciences

Research from Y.X. Wang and co-authors reveals new findings on life sciences

Published in Proteomics Weekly, October 19th, 2009

"The insulin-linked polymorphic region (ILPR) is a regulatory sequence in the promoter region upstream of the human insulin gene and is widely recognized as a locus of type I diabetes susceptibility. Polymorphism of the ILPR sequence can affect expression of both insulin and the adjacent insulin-like growth factor 2 (IGF-2) gene," scientists writing in the journal Biochemistry report.

"Several ILPR variants form G-quadruplex DNA structures in vitro that exhibit affinity binding to insulin and IGF-2. It has been Suggested that the ILPR may form G-quadruplexes in vivo as well, raising the possibility that insulin and IGF-2 may bind to these structures in the ILPR...

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Source: Proteomics Weekly (2009-10-19)

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