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University of California - San Francisco

Estrogen link in male aggression sheds new light on sex-specific behaviors

Published in Proteomics Weekly, October 19th, 2009

Territorial behavior in male mice might be linked to more "girl-power" than ever suspected, according to new findings at UCSF. For the first time, researchers have identified networks of nerve cells in the brain that are associated with how male mice defend their territory and have shown that these cells are controlled by the female hormone estrogen.

The research suggests a pivotal role for estrogen - as well as the enzyme aromatase that is responsible for estrogen synthesis - in male territorial behavior, according to findings published in the October 2, 2009 issue of the journal Cell. The paper, based on research at UCSF and Fujita Health University, also appears...

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